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学術研究実績

2020年度

原著論文

  • Sauriasari R, Sekar AP, Aisyar N, Syahdi RR, Matsuura E. Sera anti-P53 antibody provides new information which explains the link between diabetes and cancer. Diabetes Metab Syndr Obes 13:325-331, 2020.
  • Ide M, Yoshida I, Kumagai M, Mishima T, Takahashi Y, Fujita K, Igarashi T, Matsuura E. Tithonia diversifolia-derived orizabin suppresses cell adhesion, differentiation, and oxidized LDL accumulation by Akt signaling suppression via PTEN promotion in THP-1 cells. J Food Biochem 2020. 44(7). doi.org/10.1111/jfbc.13268
  • Tan, X W, Takenaka F, Takekawa H, & Mastuura E. Rapid and specific detection of oxidized LDL/β2GPI complexes via facile lateral flow immunoassay. Heliyon 6, 2020. doi.org/10.1016/j.heliyon.2020.
  • Shen L, Yamamoto T, Tan XW, Ogata K, Ando E, Ozeki E, Matsuura E. Identification and visualization of oxidized lipids in atherosclerotic plaques by microscopic imaging mass spectrometry-based metabolomics. Atherosclerosis 311, 1-12, 2020. doi.org/10.1016/j.atherosclerosis.2020.08.001.
  • Tan XW, Kobayashi K, Shen L, Inagaki J, Ide M, Hwang SS, Matsuura E. Antioxidative attributes of rice bran extracts in ameliorative effects of atherosclerosis-associated risk factors Heliyon 6, 2020. doi.org/10.1016/j.heliyon.2020.
  • Zhang Y, Chen B, Xu P, Liu C, Huang P.: Reprogramming Prostate Cancer Cells into Induced Pluripotent Stem Cells: a Promising Model of Prostate Cancer Stem Cell Research. Cell Reprogram (2020) 22, 262-268.
  • Xu N, Lin W, Sun J, Sadahira T, Xu A, Watanabe M, Guo K, Araki M, Li G, Liu C, Nasu Y, Huang P.: Nitroxoline inhibits bladder cancer progression by reversing EMT process and enhancing anti-tumor immunity. J Cancer (2020) 11, 6633-6641.

症例報告

  • Yu Z, Lin W, Xu A, Liu C, Li H, Huang P.: Percutaneous Nephrolithotomy under Local Infiltration Anesthesia in Kneeling Prone Position for a Patient with Spinal Deformity Acta Med Okayama (2020) 74, 175-178.

2019年度

原著論文

  • Xu N, Huang L, Li X, Watanabe M, Li C, Xu A, Liu C, Li Q, Araki M, Wada K, Nasu Y, Huang P: The Novel Combination of Nitroxoline and PD-1 Blockade, Exerts a Potent Antitumor Effect in a Mouse Model of Prostate Cancer International Journal of Biological Sciences (2019) 15, 919-928.
  • Fang X, Huang LL, Xu J, Ma CQ, Chen ZH, Zhang Z, Liao CH, Zheng SX, Huang P, Xu WM, Li N, Sun L: Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis Developmental Biology (2019) 454, 118-127.
  • Yakushiji H, Kobayashi K, Takenaka F, Kishi Y, Shinohara M, Akehi M, Sasaki T, Ohno E, Matsuura E.: Novel single‐chain variant of antibody against mesothelin established by phage library. Cancer Science (2019) 110, 2722-2733.

2018年度

原著論文

  • Lin W, Xie J, Xu N, Huang L, Xu A, Li H, Li C, Gao Y, Watanabe M, Liu C, Huang P: Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells. Int J Biol Sci (2018) 14, 418-426.
  • Xu N, Li X, Watanabe M, Ueki H, Hu H, Li N, Araki M, Wada K, Xu A, Liu C, Nasu Y, Huang P: Induction of cells with prostate cancer stem-like properties from mouse induced pluripotent stem cells via conditioned medium. Am J Cancer Res (2018) 8, 1624-1632.
  • Xie J, Lin W, Huang L, Xu N, Xu A, Chen B, Watanabe M, Liu C, Huang P: Bufalin suppresses the proliferation and metastasis of renal cell carcinoma by inhibiting the PI3K/Akt/mTOR signaling pathway. Oncol Lett. (2018) 16, 3867-3873.
  • Ames PRJ, Lopez LL, Merashli M, Matsuura E. : Platelet-activating factor acetylhydrolase in primary antiphospholipid syndrome. Autoimmun Highlights (2018) 9, .
  • Shen L, Azmi NU, Tan XW, Yasuda S, Wahyuningsih AT, Inagaki J, Kobayashi K, Ando E, Sasaki T, Matsuura E.: Mutants of β2-glycoprotein I: Their features and potent applications. Best Pract Res Clin Rheumatol (2018) 32, 572-590.
  • 竹中文章、小林和子、木村俊作、小関英一、大槻高史、小渕浩嗣、松浦栄次: 89Zr標識ヒト抗体バリアントと新規DDSキャリアによる Theranostics技術 Drug Delivery System (2018) 33, 214-222.  

2017年度

原著論文

  • Sasaki T, Kobayashi K, Kita S, Kojima K, Hirano H, Shen L, Takenaka F, Kumon H, Matsuura E. In vivo distribution of single chain variable fragment (scFv) against atherothrombotic oxidized LDL/β2-glycoprotein I complexes into atherosclerotic plaques of WHHL rabbits: Implication for clinical PET imaging. (Original) Autoimmun Rev 16:159-167, 2017.
  • Watanabe H, Watanabe KS, Liu K, Hiramatsu S, Zegger S, Ohashi K, Katsuyama E, Takebe N, Sada K, Akahoshi A, Takenaka F, Hanada T, Akehi M, Sasaki T, Matsuura E, Nishibori M, Wada J. Effects of anti-high mobility group box 1 antibody for MRL/lpr lupus-prone mice. Mol Ther Methods Clin Dev 6:31-39, 2017.
  • Li J, Xiu Z, Wang R, Yu C, Chi Y, Qin J, Fu C, Matsuura E, Liu Q. The lipid moiety 7-ketocholesteryl-9-carboxynonanoate mediates binding interaction of oxLDL to LOX-1 and upregulates ABCA1 expression through PPARγ. Life Sci 177:127-40. 2017.
  • Wang C, Wang Q, Li X, Jin Z, Xu P, Xu N, Xu A, Xu Y, Zheng S, Zheng J, Liu C, Huang P.: Lycorine induces apoptosis of bladder cancer T24 cells by inhibiting phospho-Akt and activating the intrinsic apoptotic cascade. Biochem Biophys Res Commun (2017) 483, 197-202.
  • Xu P, Xu A, Chen B, Zheng S, Xu Y, Li H, Li B, Huang P, Zhang Y, Ge Y, Liu C.: Ligation-free technique for dorsal vascular complex control during laparoscopic radical prostatectomy: a single-center experience from China. World J Urol (2017) 35, 402.
  • Li X, Xu P, Wang C, Xu N, Xu A, Xu Y, Sadahira T, Araki M, Wada K, Matsuura E, Watanabe M, Zheng J, Sun P, Huang P, Nasu Y, Liu C.: Synergistic effects of the immune checkpoint inhibitor CTLA-4 combined with the growth inhibitor lycorine in a mouse model of renal cell carcinoma. Oncotarget (2017) 8, 21186.
  • Xu J, Sadahira T, Kinoshita R, Li SA, Huang P, Wada K, Araki M, Ochiai K, Noguchi H, Sakaguchi M, Nasu Y, Watanabe M.: Exogenous DKK-3/REIC inhibits Wnt/β-catenin signaling and cell proliferation in human kidney cancer KPK1. Oncol Lett (2017) 14, 5642.

2016年度

原著論文

  • Arum Tri Wahyuningsih, Shen L, Kobayashi K, Sasaki T, Takenaka F, Hanada T, Akehi M, Akahoshi A, Ozeki E, Ando E, Matsuura E.: The function of β2-glycoprotein I in angiogenesis and its in vivo distribution in tumor xenografts. Acta Med Okayama (2016) 70, 13-24.
  • Akahoshi A, Matsuura E, Ozeki E, Matsui H, Watanabe K, Ohtsuki T.: Enhanced cellular uptake of lactosomes using cell-penetrating peptides. Sci Tech Adv Materials (STAM) (2016) 17, 245-252.
  • Xu P, Xu N, Guo K, Xu A, Takenaka F, Matsuura E, Liu C, Kumon H, Huang P.: Real-time monitoring of tumor progression and drug responses in a preclinical mouse model of prostate cancer. Oncotarget (2016) 7, 33025-33034.
  • Tan XW, Bhave M, Fong AY, Matsuura E, Kobayashi K, Shen LH, Hwang SS.: Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2-1) Cardiomyocytes. Oxid Med Cell Longev (2016) 6943053, .
  • Zhang Y, Li P, Xu A, Chen J, Ma C, Sakai A, Xie L, Wang L, Na Y, Kaku H, Xu P, Jin Z, Li X, Guo K, Shen H, Zheng S, Kumon H, Liu C, Huang P.: Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people. Tumour Biol (2016) 37, 6653-6659.
  • Tian JF, Li PJ, Li XX, Sun PH, Gao H, Liu XZ, Huang P, Tang JS, Yao XS.: New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae. Bioorg Med Chem Lett (2016) 26, 1391-1396.
  • Ruma IM, Putranto EW, Kondo E, Murata H, Watanabe M, Huang P, Kinoshita R, Futami J, Inoue Y, Yamauchi A, Sumardika IW, Youyi C, Yamamoto K, Nasu Y, Nishibori M, Hibino T, Sakaguchi M.: MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-κB and ROS formation upon ligand binding. Clin Exp Metastasis (2016) 33, 309-627.

2015年度

原著論文

  • Kobayashi K, Sasaki T, Takenaka F, Yakushiji H, Fujii Y, Kishi Y, Kita S, Shen L, Kumon H, Matsuura E.: A novel PET imaging using 64Cu-labeled monoclonal antibody against mesothelin commonly expressed on cancer cells. J Immunol Res (2015)
  • Kobayashi T, Furusawa Y, Yamada S, Akehi M, Takenaka F, Sasaki T, Akahoshi A, Hanada T, Matsuura E, Hirano H, Tai A, Kakuta H.: Positron Emission Tomography to Elucidate Pharmacokinetic Differences of Regioisomeric Retinoid X Receptor Agonists ACS Med Chem Lett (2015) 6, 334-338.
  • Iguchi Y, Michiue H, Kitamatsu M, Hayashi Y, Takenaka F, Nishiki T, Matsui H: Tumor-specific delivery of BSH-3R for boron neutron capture therapy and positron emission tomography imaging in a mouse brain tumor model. Biomaterials (2015) 56, 10-17.
  • Kinoshita R.,Watanabe M.,Huang P.,Li SA.,Sakaguchi M.,Kumon H.,Futami J.: The cysteine-rich core domain of REIC/Dkk-3 is critical for its effect on monocyte differentiation and tumor regression Oncol Rep (2015) 33, 2908-2914.
  • Guo K, Huang P, Xu N, Xu P, Kaku H, Zheng S, Xu A, Matsuura E, Liu C, Kumon H: A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model Oncotarget (2015) 6, 21137-21147.
  • Zhang Y, Li P, Xu A, Chen J, Ma C, Sakai A, Xie L, Wang L, Na Y, Kaku H, Xu P, Jin Z, Li X, Guo K, Shen H, Zheng S, Kumon H, Liu C,Huang P: Influence of a single-nucleotide polymorphism of the DNA mismatch repair-related gene exonuclease-1 (rs9350) with prostate cancer risk among Chinese people. Tumor Biol (2015) Epub ahead of print,
  • Tada Y, Yagi K, Uno M, Matsushita N, Kanematsu Y, Kuwayama K, Shimada K, Nishi K, Hirasawa M, Satomi J, Kitazato KT, Kageji T, Matsuura E, Nagahiro S. Improvement of Plasma Biomarkers after Switching Stroke Patients from Other Angiotensin II Type I Receptor Blockers to Olmesartan. J Stroke Cerebrovasc Dis 24:1487-1492, 2015.

2014年度

原著論文

  • Chi Y, Wang L, Liu Y, Ma Y, Wang R, Han X, Qiao H, Lin J, Matsuura E, Liu S, Liu Q.: 7-ketocholesteryl-9- carboxynonanoate enhances ATP binding cassette transporter A1 expression mediated by PPARγ in THP-1 macrophages. Atherosclerosis (2014) 234, 461-468.
  • Li J, Chi Y, Liu S, Wang L, Wang R, Han X, Matsuura E, Liu Q: Recombinant domain V of β2-glycoprotein I inhibits the formation of atherogenic oxLDL/β2-glycoprotein I complexes. J Clin Immunol (2014) 34, 669-676.
  • Kumon H, Matsuura E, Nagaoka N, Yamamoto T, Uehara S, Araki M, Matsunami Y, Kobayashi K, Matsumoto A.: Ectopic calcification: importance of common nanoparticle scaffolds containing oxidized acidic lipids. Nanomedicine (2014) 10, 441-450.

総説

  • Lopez LR, Guyer KE, Torre IG, Pitts KR, Matsuura E, Ames PR.: Platelet thromboxane (11-dehydro-Thromboxane B2) and aspirin response in patients with diabetes and coronary artery disease. World J Diabetes (2014) 5, 115-127.
  • Matsuura E, Atzeni F, Sarzi-Puttini P, Turiel M, Lopez LR, Nurmohamed MT.: Is atherosclerosis an autoimmune disease? BMC Medicine (2014) 12, 5pages.

報告書

  • 松浦栄次: ヒト抗体バリアントを用いる革新的標的医療(同時治療・診断)に向けた基盤技術構築(サブグループ1:抗体バリアントの作製およびDDS製剤の調整・評価系の確立) 平成25年度特別電源所在地県科学技術振興事業 研究成果報告書. 岡山 (2014) 57-58.
  • 松浦栄次: 線溶系代謝物を用いる病原性血管新生の標的医療(画像診断と同時治療法)の開発 文部科学省科学研究費助成事業 基盤研究(B) 研究成果報告書. (2014)

2013年度

原著論文

  • Páez MC, Matsuura E, Díaz LA, Shoenfeld Y, Serrano NC, Anaya JM. : Laminin-1 (LM-111) in preeclampsia and systemic lupus erythematosus. Autoimmunity (2013) 46, 14-20.
  • Li W, Wang D, Chi Y, Wang R, Zhang F, Ma G, Chen Z, Li J, Liu Z, Matsuura E, Liu Q. : 7-Ketocholesteryl-9- carboxynonanoate enhances the expression of ATP-binding cassette transporter A1 via CD36. Atherosclerosis (2013) 26, 102-109.

報告書

  • 阪口政清、榎本秀一、大槻高史、松浦栄次: OMICにおける標的医療に向けた基盤技術の創成: 抗体プローブ開発とその応用 平成24年度特別電源所在地県科学技術振興事業 研究成果報告書. 岡山 (2013) 27-39.
  • 小林和子、申蓮花、佐々木崇了、松浦栄次、小関英一: 生活習慣病の病態解析に資する特異抗体による精製プロセスと質量分析による酸化脂質プロファイルの作成 平成24年度JST研究成果最適展開支援プログラムA-step FSステージ探索タイプ報告書. (2013)
  • 松浦栄次、佐々木崇了、竹中文章、小林和子、喜多祥一: PET・SPECT画像診断に最適な放射標識低分子抗体バリアントの製造開発 平成24年度JST研究成果最適展開支援プログラムA-step FSステージ探索タイプ報告書. (2013)
  • 松浦栄次、小林和子: 特異抗体によるがんの標的医療(画像診断と同時治療法)の開発 文部科学省科学研究費助成事業 挑戦的萌芽研究 報告書. (2013)

2012年度

原著論文

  • Matsuura E, Guyer K, Yamamoto H, Lopez LR, Inoue K.: On aspirin treatment but not baseline thromboxane B2 levels predict adverse outcomes in patients with acute coronary syndromes. J Thromb Haemost. (2012) 10, 1949-1951.
  • Ames PR, Batuca JR, Muncy IJ, De La Torre IG, Pascoe-Gonzales S, Guyer K, Matsuura E, Lopez LR.: Aspirin insensitive thromboxane generation is associated with oxidative stress in type 2 diabetes mellitus. Thromb Res. (2012) 130, 350-354.
  • Quan N, Kobayashi K, Matsunami Y, Ide M, Makarova M, Shen L, Ohno S, Zheng Y, Kobayashi H, Lopez LR, Matsuura E.: Persimmon (Diospyros Kaki Thunb ‘Saijo’) Peel Improved Dyslipidemia and its Related Production of Atherogenic Autoantigen Complexes in Low-Density Lipoprotein Receptor-Deficient Mice. The Open Nutrition Journal (2012) 6, 12-20.

総説

  • Matsuura E, Lopez LR, Shoenfeld Y, Ames PR.: β2-glycoprotein I and oxidative inflammation in early atherogenesis: a progression from innate to adaptive immunity? Autoimmun Rev. (2012) 12, 241-249.

報告書

  • 松浦栄次、小林和子、阪口政清、大槻高史、榎本秀一: OMICにおける標的医療に向けた基盤技術の創成: 抗体プローブ開発とその応用 平成23年度特別電源所在地県科学技術振興事業 研究成果報告書. 岡山 (2012) 29-40.
  • 佐々木崇了、申蓮花、小林和子、松浦栄次: 飛行時間型質量分析装置と抗体アレイを駆使した脂質代謝異常の新規診断法の開発 平成23年度JST研究成果最適展開支援プログラムA-step FSステージ探索タイプ報告書. (2012)
  • 荒木元朗、岩佐進、小林和子、松浦栄次: 異所性石灰化を的確に診断するためのPET画像診断技術の開発 平成23年度JST研究成果最適展開支援プログラムA-step FSステージ探索タイプ報告書. (2012)
  • 松浦栄次、小林和子、佐々木崇了: 線溶系代謝物を用いる病原性血管新生の標的医療に関する研究 平成23年度JST研究成果最適展開支援プログラムA-step FSステージ探索タイプ報告書. (2012)

2011年度

原著論文

  • Shen L, Matsunami Y, Quan N, Kobayashi K, Matsuura E, Oguma K.: In vivo oxidation, platelet activation and simultaneous occurrence of natural immunity in atherosclerosis-prone mice. Isr Med Assoc J (2011) 13, 278-283.
  • Inagaki J, Hao L, Nakatsuka M, Yasuda T, Hiramatsu Y, Shoenfeld Y, Matsuura E.: A possible mechanism of autoimmune-mediated infertility in women with endometriosis. Am J Reprod Immunol (2011) 66, 90-99.
  • Zhang Y, Li W, Chi Y, Wang R, Wang D, Zhang F, Liu Z, Matsuura E, Liu Q.: Recombinant domain V of β2-glycoprotein I inhibits the formation of a 7-ketocholesteryl-9-carboxynonanoate and β2-glycoprotein I complex. J Biochem (2011) 149, 35-42.
  • Toyota T, Hanafusa T, Oda T, Koumura I, Sasaki T, Matsuura E, Kumon H, Yano T, Ono T. A purification system for 64Cu produced by a biomedical cyclotron for antibody PET imaging. J Radioanalyt Nucl Chem 298:295–300, 2013.

報告書

  • 松浦栄次、小林和子、阪口政清、榎本秀一、加来田博貴: OMICにおける標的医療に向けた基盤技術の創成:抗体プローブ開発とその応用.平成22年度特別電源所在地県科学技術振興事業 研究成果報告書. 岡山 (2011) pp1-3, pp38-49.
  • 松浦栄次、小林和子、阪口政清、榎本秀一、加来田博貴: OMICにおける標的医療に向けた基盤技術の創成:抗体プローブ開発とその応用.平成22年度特別電源所在地県科学技術振興事業 研究成果報告書. 岡山 (2011) pp1-3, pp38-49.

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